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For research purposes only. Not for human or veterinary use.

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AVIONSCIENCE

Capabilities

Chemical modifications

The modification classes relevant to research peptide synthesis, grouped by what they change in the sequence. This is reference terminology used across our specifications.

Modification classes by what they change

A modification class listed here is not a statement that a given compound carries it. Per-compound detail sits in the compound record.

Backbone and sequence-level

Changes to the peptide backbone or chirality that affect conformation and proteolytic stability.

  • Retro-inverso sequences
  • D-enantiomer and non-standard amino acid incorporation
  • N-methylated amino acids
  • Reduced peptide bonds

Terminal functionalisation

Modifications applied at the N- or C-terminus of the sequence.

  • N-terminal acetylation, formylation and acylation
  • C-terminal amidation
  • C-terminal alcohol and aldehyde moieties
  • C-terminal ester and thioester groups
  • Biotinylation

Side-chain modifications

Post-translational-type modifications and small-group additions on amino acid side chains.

  • Phosphorylation and sulfation
  • Methylation and alkylation
  • Lipidation
  • Maleimide handles for thiol conjugation
  • Side-chain acylation

Cyclisation and crosslinking

Conformational constraints introduced for structural or stability reasons.

  • Head-to-tail and side-chain cyclisation
  • Lactam bridge and thioether linkages
  • Hydrocarbon-stapled sequences
  • Multiple disulfide bond formation

Conjugation and ligation

Chemistries used to join sequences or attach a payload.

  • Native chemical, oxime and click-assisted ligation
  • Conjugation to small molecules
  • Conjugation to polymers, including PEGylation
  • Clickable azide and alkyne handles

Labels, dyes and reporters

Detection handles used in assay and analytical work.

  • Dye-labelled sequences
  • Fluorophore and chromophore incorporation
  • Chromogenic and fluorogenic substrates
  • Biotin labelling

Modification detail for a specific compound is stated on the record for that compound.

Where this connects

Modification classes describe chemistry. The capability and compound pages describe what has been produced and documented.

Avion Science manufactures peptide compounds for laboratory research use only. This website is informational: nothing is offered for sale, and nothing published here is medical advice, a dosing protocol or a claim of therapeutic effect.